Dr. Srougi earned her B.S. in Biology from the University of Toledo in 2001, and her Ph.D. in Pharmacology from Case Western Reserve University in 2007. Her graduate work, under the supervision of Dr. David A. Boothman, focused on the cellular mechanisms of a novel cancer chemotherapeutic agent beta-lapachone with an emphasis on the DNA damage response. Following completion of her doctoral studies, she completed a post-doctoral fellowship with Dr. Keith Burridge at the University of North Carolina at Chapel Hill where she studied the regulation of the Rho family of small GTPases after DNA damage. Dr. Srougi joined the Biotechnology Program at North Carolina State University in 2011.
1. Srougi, M.C., Miller, H.B., Witherow, D.S., and Carson, S. Assessment of a Novel Group-Centered Testing Schema in an Upper-Level Undergraduate Molecular Biotechnology Course. (2013) BAMBED, in press.
2. Dubash, A.D., Guilluy, C., Srougi, M.C., Boulter, E, Burridge, K., and Garcia-Mata R. The Small GTPase RhoA Localizes to the Nucleus and is Activated by Net1 and DNA Damage Signals. (2011) PLoS One, 6(2), e17380.
3. *Srougi, M.C., and Burridge, K. The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death After DNA Damage. (2011) PLoS One, 6(2), e17108.
*paper selected for review by the Faculty of 1000
4. Srougi, M.C., and Burridge, K. Undressing a Cellular Corset: Septins Exposed. (2009) Nature Cell Biology, 11(1),9-10.
5. Bey, E.A., Bentle, M.S., Reinicke, K.E., Dong, Y., and Boothman, D.A. A Novel NQO1-Mediated and PARP-1-Mediated Cell Death Pathway Induced in Non-Small Cell Lung Cancer Cells by β-Lapachone. (2007) Proceedings of the National Academy of Science USA, 104(28), 11832-11837.
6. Bentle, M.S., Dong, Y., Reinicke, K.E., Bey, E.A., and Boothman, D.A. Non-Homologous End Joining is Essential for Cellular Resistance to the Novel Chemotherapeutic Agent β-Lapachone. (2007) Cancer Research, 67(14), 6936-45.
7. Bentle, M.S., Reinicke, K.E., Bey, E.A., Spitz, D.R., and Boothman, D.A. Calcium-Dependent Modulation of PARP-1 Alters Cellular Metabolism and DNA Repair. (2006) The Journal of Biological Chemistry, 281(44), 33684-33696.
8. Bey, E.A., Wuerzberger-Davis, S.M., Pink, J.J., Yang, C.R., Araki, S., Reinicke, K.E., Bentle, M.S., Dong, Y., Cataldo, E., Criswell, T.C., Wagner, M.W., Li, L., Gao, J., and Boothman, D.A. Mornings with Art, Lessons Learned: Feedback Regulation, Restriction Threshold Biology, and Redundancy Govern Molecular Stress Responses. (2006) The Journal of Cellular Physiology, 209(3), 604-610.
9. Bentle, M.S., Bey, E.A., Dong, Y., Reinicke, K.E., and Boothman, D.A. New Trick for Old Drugs: The Anticarcinogenic Potential of DNA Repair Inhibitors. (2006) The Journal of Molecular Histology, 37(5-7), 203-218.
10. Reinicke, K.E., Bey, E.A., Bentle, M.S., et. al. Development of β-Lapachone Prodrugs for Therapy Against Human Cancers with Elevated NAD(P)H:Quinone Oxidoreductase I Levels. (2005) Clinical Cancer Research, 11(8), 3055-64.
When not teaching or working in the lab, Melissa enjoys being outdoors, running, and reading. She also loves to spend her free time with her two favorite boys, Scott and Hunter.