Leigh Ann Samsa

Teaching Postdoctoral Scholar
Education

B.S. Duke University
Ph.D. UNC-Chapel Hill

Courses

  • Manipulation of Recombinant DNA: Core Technologies in Molecular Biology

Research

Cell and molecular physiology.

 

Publications

Samsa LA, Williamson IA, Magness, ST. Quantitative Analysis of Intestinal Stem Cell Dynamics Using Microfabricated Cell Culture Arrays. Somatic Stem Cells-Methods and Protocols, Vol 2. In press. Link: Available soon!

Samsa LA and G Samsa. A guide to reproducibility in preclinical research. Academic Medicine. 2018. In press. Link: Available soon!

Williamson IA, Arnold JW, Samsa LA, Gaynor L, DeSalvo M, Cocchiara J, Carroll I, Azcarate-Peril A, Rawls J, Allbritton NL, Magness ST. Investigating host-microbe interactions using high-throughput microinjection into gut organoids. Cell and Molecular Gastroenterology and Hepatology.. 2018. In Press. Link: https://doi.org/10.1016/j.jcmgh.2018.05.004

Zwarycz B, Gracz AD, Rivera KR, Williamson IA, Samsa LA, Salter-Sid L, Zhao Q, Magness ST. A focused screen of inflammatory bowel disease cytokines reveals IL22-dependent inhibition of stem cell expansion in an ileal organoid model. ICell and Molecular Gastroenterology and Hepatology. 2018. In press. Link: https://doi.org/10.1016/j.jcmgh.2018.06.008

Fleming ND, Samsa LA, Hassel D, Qian L, Liu J. Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation. Scientific Reports. 2018;8(1):8584. Link: https://doi.org/10.1038/s41598-018-26843-1

Brown D*, Samsa LA*, Ito C, Ma H, Batres K, Aranout R, Qian L, Liu J. Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of cellular and molecular medicine. 2017; 22(3):2007-2017. *Authors contributed equally. Link: https://doi.org/10.1111/jcmm.13408  

Haskell GT, Jensen BC, Samsa LA, Marchuk D, Huang W, Skrzynia C, Tilley C, Seifert BA, Rivera-Muñoz EA, Koller B, Wilhelmsen KC, Liu J, Alhosaini H, Weck KE, Evans JP, Berg JS. Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. Circulation. Cardiovascular genetics. 2017; 10(3). Link: https://doi.org/10.1161/CIRCGENETICS.116.001443

Samsa LA, Ito CE, Brown DR, Qian L, Liu J. IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac Trabeculation in Zebrafish. PloS one. 2016; 11(11):e0166734. Link: https://doi.org/10.1371/journal.pone.0166734

Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6.  Nature communications. 2016; 7:13247. Link: https://doi.org/10.1038/ncomms13247

Brown DR, Samsa LA, Qian L, Liu J. Advances in the Study of Heart Development and Disease Using Zebrafish. Journal of cardiovascular development and disease. 2016; 3(2). Link: https://doi.org/10.3390/jcdd3020013

Samsa LA, Fleming N, Magness S, Qian L, Liu J. Isolation and Characterization of  Single Cells from Zebrafish Embryos. Journal of visualized experiments: JoVE. 2016; (109). Link: https://doi.org/10.3791/53877

Samsa LA, Givens C, Tzima E, Stainier DY, Qian L, Liu J. Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish. Development (Cambridge, England). 2015; 142(23):4080-91. Link: https://doi.org/10.1242/dev.125724

Bohórquez DV, Samsa LA, Roholt A, Medicetty S, Chandra R, Liddle RA. An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy.  PloS one. 2014; 9(2):e89881. Link: https://doi.org/10.1371/journal.pone.0089881

Samsa LA, Yang B, Liu J. Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation. American journal of medical genetics. Part C, Seminars in medical genetics. 2013; 163C(3):157-68. Link: https://doi.org/10.1002/ajmg.c.31366

Wang Y, Chandra R, Samsa LA, Gooch B, Fee BE, Cook JM, Vigna SR, Grant AO, Liddle RA. Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. American journal of physiology. Gastrointestinal and liver physiology. 2011; 300(4):G528-37. Link: https://doi.org/10.1152/ajpgi.00387.2010

Bohórquez DV, Chandra R, Samsa LA, Vigna SR, Liddle RA. Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. Journal of molecular histology. 2011; 42(1):3-13. Link: https://doi.org/10.1007/s10735-010-9302-6

Chandra R, Samsa LA, Vigna SR, Liddle RA. Pseudopod-like basal cell processes in intestinal cholecystokinin cells. Cell and Tissue Research. 2010; 341(2):289-297. Link: .https://doi.org/10.1007/s00441-010-0997-1

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