Dr. Ott received her B.S. in Microbiology from Michigan State University in 2005 and completed her Ph.D. in Immunology from NC State University in 2010. Her graduate work, under the direction of Dr. Samuel Jones and Dr. Jeffrey Yoder (NCSU College of Veterinary Medicine), studied the role of myristoylated alanine-rich C-kinase substrate (MARCKS) in inflammation, with a particular focus on cell migration. Upon completion of her doctoral studies, Dr. Ott joined the lab of Dr. Jonathan Serody at the University of North Carolina at Chapel Hill where she studied the role of T helper cells in the pathogeneis of graft-versus-host disease. Dr. Ott joined the Biotechnology Program at NC State University in January 2012, a position that she was very excited to accept given that she took courses from the Biotechnology Program while in graduate school.
Dr. Ott's research interests include the role of myristoylated alanine-rich C-kinase substrate (MARCKS) in immune cell function, with particular interests in neutrophils, monocytes and T cells. She has mentored undergraduate students in various summer projects, including evaluating the regulation of MARCKS expression in lipopolysaccharide-stimulated monocytes and optimization of T cell transfection using a liposomal reagent.
She is also interested in the scholarship of teaching and learning (SoTL) and is currently working on two projects. In the first project, she designed a course (Immunology Methods) on the use of flow cytometry and enzyme-linked immunosorbent assay (ELISA), which are two commonly used immunological techniques. In the second project, Dr. Ott designed an inquiry-based laboratory exercise for the Current Topics in Biotechnology course, where students design and implement molecular biology experiments to solve a crime.
(* denotes undergraduate co-author):
Ott LE, Carson S. Immunological Toos: Engaging Students in the Use and Analysis of Flow cytometry and Enzyme-Linked Immunosorbent Assay (ELISA). Biochemistry and Molecular Biology Education (In Press), 2014
Ott LE, Sung EJ, Melvin AT, Sheats MK, Haugh JM, Adler KA, Jones SL. Fibroblast migration is regulated by myristoylated alanine-rich C-kinase substrate (MARCKS) protein. PloS One 8: e66512, 2013
Fulton LM, Carlson MJ, Coghill JM, Ott LE, West ML, Panoskaltsis-Mortari A, Littman DR, Blazar BR, Serody JS. Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt. Journal of Immunology 189: 1765, 2012
Ott LE, McDowell ZT*, Turner PM, Law JM, Yoder JA, Jones SL. Two myristoylated alanine-rich C-kinase substrate (MARCKS) paralogs are required for normal development of zebrafish. Anatomical Record 294: 1511, 2011
Eckert RE, Neuder LE, Park J, Adler KB, Jones SL. Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration. Am J Respir Cell Mol Biol. 42: 586, 2010
Neuder LE, Keener JM*, Eckert RE, Trujillo JC, Jones SL. Role of p38 MAPK in pro-inflammatory cytokine and chemokine expression in equine leukocytes. Vet Immuno Immunopath. 129: 192, 2009
Cook VL, Neuder LE, Blikslager AT, Jones SL. The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. Vet Immunol Immunopath 129: 137, 2009
Eckert RE, Neuder LE, Bell JL, Trujillo JC, Jones SL. The role of p38 mitogen-activated protein kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes. Vet Immunol Immunopath 118: 294, 2007
In her spare time, Dr. Ott enjoys cooking, watching college football (Go Spartans!) and traveling. She also loves to spend time with her husband, daughter and pups.