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BIT 495/595: Illuminating Disease with Chemical Biology


  • Students will experience the process of designing, synthesizing, characterizing, and testing a fluorescent probe for detection and labeling of a metalloenzyme indicated in diseases, such as cancer and glaucoma. Students will gain experience with molecular docking, chemical synthesis and purification, fluorescence characterization, and fluorescence imaging.


  1. Molecular docking and probe design
  2. Chemical synthesis and purification 
  3. Mechanisms and applications of fluorescence 
  4. Enzymatic activity and inhibition 
  5. Gel electrophoresis 
  6. Fluorescence microscopy

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