BIT 495/595: Illuminating Disease with Chemical Biology

Overview:

• Students will experience the process of designing, synthesizing, characterizing, and testing a fluorescent probe for detection and labeling of a metalloenzyme indicated in diseases, such as cancer and glaucoma. Students will gain experience with molecular docking, chemical synthesis and purification, fluorescence characterization, and fluorescence imaging.

Topics:

• Molecular docking and probe design
• Chemical synthesis and purification 
• Mechanisms and applications of fluorescence 
• Enzymatic activity and inhibition 
• Gel electrophoresis 
• Fluorescence microscopy

Back to Courses