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BIT 495/595: Illuminating Disease with Chemical Biology


  • Students will experience the process of designing, synthesizing, characterizing, and testing a fluorescent probe for detection and labeling of a metalloenzyme indicated in diseases, such as cancer and glaucoma. Students will gain experience with molecular docking, chemical synthesis and purification, fluorescence characterization, and fluorescence imaging.


  • Molecular docking and probe design
  • Chemical synthesis and purification 
  • Mechanisms and applications of fluorescence 
  • Enzymatic activity and inhibition 
  • Gel electrophoresis 
  • Fluorescence microscopy

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