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Molecular Biotechnology Education

The Biotechnology Program (BIT) at NC State University.

About the image: In the BIT Organoids course, students use mouse intestinal organoids to study cancer initiation. Students transfect organoids with CRISPR/Cas9 editing tools to delete the gene Apc and a second gene of interest. Apc is an important part of the Wnt pathway, and disrupted Wnt signaling is a key early change that happens in intestinal cancer. This image shows a brightfield image of a CRISPR/Cas9-editing Apc-knockout organoid that is thriving in conditions that have killed the non-knockout cells around it. Image credits: Taylor Roberts (transfection) and Ravi Appalabhotla (CRISPR knockout) in Dr. Leigh Ann Samsa’s class.

New award! Congratulations to Dr. Dums for receiving a Postdoctoral Meeting Award to present his pedagogical work on growth mindset at the ASBMB 2021 National Meeting.

New DELTA Course Design Grant:  The BIT team received a DELTA Course Design Grant to develop an online BIT 410/510 course: EASEE Enhancing Access to Science Through Equitable online Education.”

Re-designed course launched this fall: BIT 474/574: Plant Genetic Engineering

New publications: Dr. Arnab Sengupta published his research in the prestigious journal Nature Communications!

van der Stel, AX., Gordon, E.R., Sengupta, A. et al. Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling. Nat Commun 12, 5340 (2021). https://doi.org/10.1038/s41467-021-25663-8

Collaborations: BIT leads a multi-institution project to expand Molecular Biotechnology Laboratory Education Modules (MBLEMs) with five partner institutions.