BIT 495/595: Illuminating Disease with Chemical Biology

Overview:

• Students will experience the process of designing, synthesizing, characterizing, and testing a fluorescent probe for detection and labeling of a metalloenzyme indicated in diseases, such as cancer and glaucoma. Students will gain experience with molecular docking, chemical synthesis and purification, fluorescence characterization, and fluorescence imaging.

Topics:

1. Molecular docking and probe design
2. Chemical synthesis and purification 
3. Mechanisms and applications of fluorescence 
4. Enzymatic activity and inhibition 
5. Gel electrophoresis 
6. Fluorescence microscopy

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